Team, Visitors, External Collaborators
Overall Objectives
Research Program
Application Domains
Highlights of the Year
New Software and Platforms
New Results
Bilateral Contracts and Grants with Industry
Partnerships and Cooperations
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Section: New Software and Platforms


Testing HypOtheses for diffusion TricHotomy

Keywords: Photonic imaging - Fluorescence microscopy - Biomedical imaging - Classification - Statistical categorisation techniques - Statistics - Image sequence - Visual tracking

Functional Description: The THOTH software classifies biomolecule trajectories of biomolecules (computed with tracking algorithms) into three groups of diffusion: (i) free diffusion, (ii) subdiffusion or (iii) superdiffusion. Brownian motion corresponds to the NULL hypothesis. THOTH is a nonparametric three-decision test whose alternatives are subdiffusion and superdiffusion. Single and multiple testing procedures control respectively the type I error and the false discovery rate. THOTH can be considered as an alternative to the Mean Square Displacement (MSD) method commonly used to address this issue. It gives more reliable results as confirmed by our Monte Carlo simulations and evaluations on real sequences of images depicting protein dynamics acquired with TIRF or SPT-PALM microscopy.