Team, Visitors, External Collaborators
Overall Objectives
Research Program
Application Domains
Highlights of the Year
New Software and Platforms
New Results
Bilateral Contracts and Grants with Industry
Partnerships and Cooperations
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Section: Application Domains

Biosensor design and implementation in non-living protocells

In collaboration with Franck Molina (CNRS, Sys2Diag, Montpellier) and Jie-Hong Jiang (NTU, Taiwan) we ambition to apply our techniques to the design and implementation of high-level functions in non-living vesicles for medical applications, such as biosensors for medical diagnosis (Alexis Courbet, Patrick Amar, Fran├žois Fages, Eric Renard, Franck Molina. Computer-aided biochemical programming of synthetic microreactors as diagnostic devices. Molecular Systems Biology, 14(4), 2018.). Our approach is based on purely protein computation and on our ability to compile controllers and programs in biochemical reactions. The realization will be prototyped using a microfluidic device at CNRS Sys2Diag which will allow us to precisely control the size of the vesicles and the concentrations of the injected proteins. It is worth noting that the choice of non-living chassis, in contrast to living cells in synthetic biology, is particularly appealing for security considerations and compliance to forthcoming EU regulation.