Team, Visitors, External Collaborators
Overall Objectives
Research Program
Application Domains
Highlights of the Year
New Software and Platforms
New Results
Bilateral Contracts and Grants with Industry
Partnerships and Cooperations
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Section: Application Domains


Genetic and cancer disease diagnostic: Genetic diseases are caused by some particular mutations in the genomes that alter important cell processes. Similarly, cancer comes from changes in the DNA molecules that alter cell behavior, causing uncontrollable growth and malignancy. Pointing out genes with mutations helps in identifying the disease and in prescribing the right drug. Thus, DNA from individual patients is sequenced and the aim is to detect potential mutations that may be linked to the patient disease. Bioinformatics analysis can be based on the detection of SNPs (Single Nucleotide Polymorphism) from a set of predefined target genes. One can also scan the complete genome and report all kinds of mutations, including complex mutations such as large insertions or deletions, that could be associated with genetic or cancer diseases.

Neurodegenerative disorders: The biological processes that lead from abnormal protein accumulation to neuronal loss and cognitive dysfunction is not fully understood. In this context, neuroimaging biomarkers and statistical methods to study large datasets play a pivotal role to better understand the pathophysiology of neurodegenerative disorders. The discovery of new genetic biomarkers could thus have a major impact on clinical trials by allowing inclusion of patients at a very early stage, at which treatments are the most likely to be effective. Correlations with genetic variables can determine subgroups of patients with common anatomical and genetic characteristics.