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Section: New Results

Strong Turing completeness of continuous CRNs

Participants : Fran├žois Fages, Guillaume Le Guludec (former Member), Sylvain Soliman.

When seeking to understand how computation is carried out in the cell to maintain itself in its environment, process signals and make decisions, the continuous nature of protein interaction processes forces us to consider also analog computation models and mixed analog-digital computation programs. However, recent results in the theory of analog computability and complexity obtained by Pouly and Bournez, establish fundamental links between analog and digital computing. In [8] and [10], we derive from these results the strong (uniform computability) Turing completeness of chemical reaction networks over a finite set of molecular species under the differential semantics, solving a long standing open problem. Furthermore we derive from the proof a compiler of mathematical functions into elementary chemical reactions. We illustrate the reaction code generated by our compiler on trigonometric functions, and on various sigmoid functions which can serve as markers of presence or absence for implementing program control instructions in the cell and imperative programs. This makes it possible to start comparing our compiler-generated circuits to the natural circuit of the MAPK signaling network, which plays the role of an analog-digital converter in the cell with a Hill type sigmoid input/output functions.