Overall Objectives
Research Program
Application Domains
New Software and Platforms
New Results
Bilateral Contracts and Grants with Industry
Partnerships and Cooperations
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Section: Application Domains

Function and history of genomes

Yeasts provide an ideal subject matter for the study of eukaryotic microorganisms. From an experimental standpoint, the yeast Saccharomyces cerevisiae is a model organism amenable to laboratory use and very widely exploited, resulting in an astonishing array of experimental results. From a genomic standpoint, yeasts from the hemiascomycete class provide a unique tool for studying eukaryotic genome evolution on a large scale. With their relatively small and compact genomes, yeasts offer a unique opportunity to explore eukaryotic genome evolution by comparative analysis of several species. MAGNOME applies its methods for comparative genomics and knowledge engineering to the yeasts through the ten-year old Génolevures program (GDR 2354 CNRS), devoted to large-scale comparisons of yeast genomes with the aim of addressing basic questions of molecular evolution.

We developed the software tools used by the CNRS's web site. For example, Magnome 's Magus system for simultaneous genome annotation combines semi-supervised classification and rule-based inference in a collaborative web-based system that explicitly uses comparative genomics to simultaneously analyse groups of related genomes.