Section: New Results

Non ribosomal peptides synthesis

Participants : Ségolène Caboche, Gregory Kucherov, Maude Pupin.

Study of NRPs monomeric composition

The rationale of a large-scale study of monomers of nonribosomal peptides is that such a study was not possible before the advent of Norine , because it requires a complete list of these peptides annotated with the list of composing monomers. We discovered a significant difference in monomeric compositions of bacterial and fungi NRPs. Moreover, the monomeric composition can often be used as a signature of the producing organism or the biological activity of the NRP. A prediction software, based on these observations, has been created. Two papers describing these findings are in preparation.

Thesis

Ségolène Caboche obtain her PhD thesis in computational science the 8th of September [12] .

External recognition

We have been contacted by the Worldwide Protein Data Bank [34] (wwPDB) that maintains a unique freely available archive of macromolecular structural data. wwPDB started to use Norine entry identifiers as external references along with the UniProt [40] (Universal Protein Resource) accession codes for gene product sequences. Recently, Norine has been described in an issue of Methods in Enzymology dedicated to microbial natural products biosynthesis [33] .