Section: New Results

Modeling G protein-Coupled Signal Transduction

Participants : François Fages, Steven Gay, Domitille Heitzler, Aurélien Rizk, Sylvain Soliman.

In collaboration with Eric Reiter (UMR CNRS-INRA 6175) and Frédérique Clément (SISYPHE) in the framework of the Initiative Action REGATE , we analyse the connectivity and dynamics of the FSH signalling network in its target cells, and embedding the network within a multi-scale representation, from the molecular up to the organic level.

We study the relative contributions of different pathways to the cell response to FSH signal, in order to determine how each pathway controls downstream cascades and which mechanisms are involved in the transition between different cellular states.

A systems biology approach is followed using BIOCHAM 's features for rule-based modeling with temporal logic constraints used for searching unknown kinetic parameter values. In [4] , this approach is applied more generally to G protein-coupled receptor signalling which is of great importance in pharmacology.