Keywords : protein domain families, database.
Participant : Daniel Kahn [ correspondent ] .
ProDom (2005; Nucleic Acids Res. 33(Database issue):212-215) is a comprehensive set of protein domain families automatically generated from the SWISS-PROT and TrEMBL sequence databases. The analysis of evolutionary scenarios of protein domain families from ProDom showed that only a small minority of domain families is truly ancestral. Far from being static, the protein domain repertoire undergoes a continuous innovation process. Therefore the tremendous diversity of modular proteins results from both the combinatorial assortment of protein domains and an ongoing process of protein domain innovation. The ProDom database is available at: http://prodom.prabi.fr/prodom/current/html/home.php .