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Section: Application Domains

Crystallography

Participants : Alexander Bockmayr, Eric Domenjoud.

X-ray structure analysis is the main tool to establish the three-dimensional atomic structure of biological macromolecules and their complexes. The determination of a structure in X-ray crystallography passes through several stages:

A key problem of X-ray structure analysis is the so-called phase problem . In an X-ray experiment, one can measure only the magnitudes of the complex Fourier coefficients of the electron density distribution under study, but not their phases. Half of the necessary information is therefore lost, and must be restored by other means.


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